Photodynamic therapy in a cell culture model of human intimal hyperplasia
نویسندگان
چکیده
منابع مشابه
Photodynamic therapy of arteries. A novel approach for treatment of experimental intimal hyperplasia.
BACKGROUND Photodynamic therapy (PDT) uses light activation of otherwise nontoxic dyes for the production of reactive oxygen species that cause cell injury and death. METHODS AND RESULTS The inhibition of intimal hyperplasia (IH) by PDT was studied in the balloon injury model of the rat carotid artery. Chloroaluminum-sulfonated phthalocyanine (CASPc) was the drug chosen for PDT because it doe...
متن کاملPhotodynamic therapy for the prevention of intimal hyperplasia in balloon-injured rabbit arteries.
This study was performed to demonstrate accumulation of the photosensitizer hematoporphyrin derivative (HPD) in atherosclerosis and to determine whether intimal hyperplasia, the main cause of restenosis after angioplasty, can be inhibited by photodynamic therapy (PDT). Forty Japanese White rabbits were subjected to balloon endothelial injury in the common iliac artery. Five groups of rabbits, i...
متن کاملEndovascular Irradiation in the Therapy of Intimal Hyperplasia.
stented vascular segments causes injuries to the vascular wall, almost always resulting in intimal hyperplasia, even after stents.1-22 A possible alternative is to combine the methods available for treating intimal hyperplasia. The results obtained in treating keloids by means of irradiation therap y2 3 3 4 was the basis for our therapeutic concept for the prophylactic irradiation of hyperproli...
متن کاملA novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model.
OBJECTIVE The present study was aimed at developing a new cell-permeant peptide inhibitor (MK2i) of the kinase that phosphorylates and activates heat-shock protein (HSP)27 (MAPKAP kinase II), and evaluating the ability of this peptide to inhibit HSP27 phosphorylation and intimal thickening. METHODS The ability of MK2i to reduce HSP27 phosphorylation and cell migration was evaluated in A7R5 ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Vascular and Endovascular Surgery
سال: 1995
ISSN: 1078-5884
DOI: 10.1016/s1078-5884(05)80017-6